Molecular characterization of adrenergic receptors.
نویسندگان
چکیده
منابع مشابه
BRIEF REVIEWS Molecular Characterization of Adrenergic Receptors
THIS is an appropriate time to review progress in the area of adrenergic receptors, particularly in terms of research that aims at achieving an understanding of these proteins at the level of their molecular composition. The past decade has seen an explosion in the field of adrenergic receptor pharmacology, made possible to a large extent by the development of the radioligand-binding assay. Alt...
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-adrenoceptor binding sites were characterized in duck cerebral cortex by an in vitro binding technique, using [ 3 H]dihydroalprenolol ([ 3 H]DHA) as a receptor-specific radioligand. The specific binding of [ 3 H]DHA to duck cerebral cortical membranes was found to be rapid, stable, saturable, reversible, and of high affinity. Saturation analysis resulted in a linear Scatchard plot suggesting b...
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alpha-Adrenergic receptor subtypes were investigated using [3H]prazosin, an alpha 1 selective antagonist, and the alpha 2 selective antagonist [3H]rauwolscine in a smooth muscle plasma membrane enriched microsomal fraction prepared from rabbit intrarenal arterial vasculature. Both radioligands displayed single components on Scatchard analysis. The specific binding of [3H]prazosin was of high af...
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The important and diverse biological functions of β-adrenergic receptors (βARs) have promoted the search for compounds to stimulate or inhibit their activity. In this regard, unraveling the molecular basis of ligand binding/unbinding events is essential to understand the pharmacological properties of these G protein-coupled receptors. In this study, we use the steered molecular dynamics simulat...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1985
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.56.5.635